I've put some thought into a layout for unarmed combat;
While defending, have your character attempt to block with their arms, making gauntlets, bracers, and spaulders extremely valuable.
Have the left and right mouse buttons control the left and right fists, a quick click results in a jab and holding the button results in a hook with left shift being a head/body shot modifier.
Press both mouse buttons quickly to shove.
Hold both mouse buttons to attempt a grapple/take down with left shift being an upper body/lower body shoot modifier.
Q for a left kick and E for a right kick. I'm thinking if you're standing still or moving forward they will perform front kicks, and if you're moving left or right attempt a roundhouse kick.
Allow for kicks to be aimed at prone opponents or add stomps for prone opponents.
And some gameplay mechanics I would like to see for combat;
Your armor adds weight to make your strikes do more blunt damage. But if you're fighting an opponent with metal armor you risk doing damage to yourself when striking the plates. Which makes using a weapon important in certain fights (fighting skeletons unarmed will be less effective as there aren't any internal organs to damage etc.).
I would also like to see some form of limb damage, a limb should only be severed if the hit results in a kill. Nothing that would hobble your character making it impossible to continue, but if a limb is damaged (when an enemy deals red damage) make it weaker. Damaged arm makes attacking/blocking slower and damaged legs makes movements using the damaged leg are slower. Allow for the healing potions to heal damaged limbs.
I absolutely love this game and the fighting mechanics. Keep up the good work guys.