Hey Rob, I've got a challenge for you but I'm not entirely sure it's possible. It's a campaign challenge. Not an arena challenge. I might try it myself.
Here are the rules:
1: You start the game naked.
2: In the starting room you may only pick up the torch.
3: Before you start needing to unlock doors to continue all the equipment that you use must be randomly generated from containers. You may not pick up any of the equippable placed items (the machete, the gloves, the cleaver lying by the dead body in that room with a locked door etc). You may still take non-equipable items (the keys, scrolls, books etc). Just not any of the obviously placed pieces of equipment.
4: Once you get to the point where you absolutely need to unlock doors to continue it starts to become pretty dangerous and you'll need to gather some equipment quickly so the no picking up stuff rules become more optional. You might actually need that mace and bill hook in the side room behind those locked doors.
As I mentioned this is probably quite a tough challenge. I'm not entirely sure how possible it is but it might be fun to try.